<![CDATA[Frontier Dispatch: Deep Tech Conversations]]>Frontier Dispatch is a podcast from Main Sequence about the people rebuilding the world's most essential systems. Every episode is a conversation from inside the work, with the founders, investors, researchers, and builders who have chosen problems that are too important to leave unsolved. Energy. Food. Health. Space. Compute. Defence. The systems the future depends on.

This is a show about what it actually takes to build at the frontier, the timelines, the capital intensity, the moments where the science finally becomes possible, and the conviction required to stay when it gets hard.

Hosted by the Main Sequence team. Produced in Australia. Pointed at the world.

]]>www.mseq.vcRiverside.fm (https://riverside.com)Mon, 27 Apr 2026 08:11:19 GMTTue, 14 Apr 2026 03:39:55 GMT60Main Sequence<p>Frontier Dispatch is a podcast from Main Sequence about the people rebuilding the world's most essential systems. Every episode is a conversation from inside the work, with the founders, investors, researchers, and builders who have chosen problems that are too important to leave unsolved. Energy. Food. Health. Space. Compute. Defence. The systems the future depends on.</p><p>This is a show about what it actually takes to build at the frontier, the timelines, the capital intensity, the moments where the science finally becomes possible, and the conviction required to stay when it gets hard.</p><p>Hosted by the Main Sequence team. Produced in Australia. Pointed at the world.</p>episodicMain Sequencepeter.chen@mseq.vcno<![CDATA[Field Work: Making the Old New Again | Michele Stansfield]]>The conversation delves into the challenges and innovations in precision fermentation, marketing deep tech, and the transition from batch to continuous fermentation. It explores the need for tech demonstration, scaling, and the deployment of new technology in the industry. Hosted by Jason Whitfield.

]]>3409b37c-3337-41ab-bd0b-3cff06554a74Tue, 14 Apr 2026 06:24:03 GMT<p>The conversation delves into the challenges and innovations in precision fermentation, marketing deep tech, and the transition from batch to continuous fermentation. It explores the need for tech demonstration, scaling, and the deployment of new technology in the industry. Hosted by Jason Whitfield.</p>no00:18:1415Field Work: Making the Old New Again | Michele Stansfieldfull<![CDATA[Long Position: Capital Flows and Conviction | Brighid Pappin]]>Brighid discusses the changes in investment conviction over the last 12-24 months, emphasizing the importance of value creation, manager synergy, and track record. She also highlights the need to cut through the noise in deep tech and the potential gaps in the capital funnel. Hosted by Elaine Stead

]]>e3b26943-559d-459d-824b-fd618be20b9bTue, 14 Apr 2026 05:57:07 GMT<p>Brighid discusses the changes in investment conviction over the last 12-24 months, emphasizing the importance of value creation, manager synergy, and track record. She also highlights the need to cut through the noise in deep tech and the potential gaps in the capital funnel. Hosted by Elaine Stead</p>no00:11:0013Long Position: Capital Flows and Conviction | Brighid Pappinfull<![CDATA[Field Work: The Next Horizon of Humanity Scale Healthcare Impact | Xoma, Xylo, and Currus Biologics]]>The conversation covers the development of novel neurotherapeutics by Xylo, the motivation and impact behind the work, Xylo's unfair advantage, Zoma Labs' continuous glucose monitoring, their unfair advantage, and Currus Biologics' cell therapy for solid tumors. Hosted by Elaine Stead.

]]>608464ca-9d6a-4f68-baba-140980db5115Tue, 14 Apr 2026 03:48:33 GMT<p>The conversation covers the development of novel neurotherapeutics by Xylo, the motivation and impact behind the work, Xylo's unfair advantage, Zoma Labs' continuous glucose monitoring, their unfair advantage, and Currus Biologics' cell therapy for solid tumors. Hosted by Elaine Stead.</p>no00:21:2012Field Work: The Next Horizon of Humanity Scale Healthcare Impact | Xoma, Xylo, and Currus Biologicsfull<![CDATA[Sharp End: "I thought I understood Amazon's 'Build Backwards' method, until I met Steve Kessel"]]>The conversation with Steve Kessel from Amazon focused on the importance of emphasizing people and processes over brute force, leadership through people and processes, and the significance of the PR FAQ process in product development. The discussion also covered the hiring for superpowers, building momentum and iteration, and the role of leadership in making judgment calls. Hosted by Phil Morle.

Takeaways

  • People and processes over brute force
  • Leadership through people and processes
  • The importance of PR FAQ process

Chapters

  • 00:00 Emphasizing People and Processes
  • 08:06 Hiring for Superpowers
  • 20:04 Building Momentum and Iteration
]]>31a9e980-76c0-4ba3-890f-ca4f488d4511Tue, 14 Apr 2026 03:44:09 GMT<p>The conversation with Steve Kessel from Amazon focused on the importance of emphasizing people and processes over brute force, leadership through people and processes, and the significance of the PR FAQ process in product development. The discussion also covered the hiring for superpowers, building momentum and iteration, and the role of leadership in making judgment calls. Hosted by Phil Morle.</p><p></p><p>Takeaways</p><ul><li>People and processes over brute force</li><li>Leadership through people and processes</li><li>The importance of PR FAQ process</li></ul><p></p><p>Chapters</p><ul><li>00:00 Emphasizing People and Processes</li><li>08:06 Hiring for Superpowers</li><li>20:04 Building Momentum and Iteration</li></ul>no00:26:5611Sharp End: "I thought I understood Amazon's 'Build Backwards' method, until I met Steve Kessel"full